With four successive defeats in all competitions, Liverpool are enduring their worst run for 22 years. A fifth reverse in a row would be their worst sequence since 1953.
Liverpool beat Manchester United home and away in the league last season and will be looking for a similarly inspired performance. A Wes Brown own-goal and a Ryan Babel strike handed Liverpool the Anfield victory after Carlos Tevez had given United an early lead.
Liverpool Team News
Liverpool manager Rafael Benitez will give his injured trio of Steven Gerrard, Fernando Torres and Glen Johnson every chance to prove their fitness. Gerrard is the biggest concern of the groin injury victims but he received treatment on Friday, and that will continue right up until the Anfield match.
Torres and Johnson are much closer to being confirmed in the starting line-up ahead of the match but winger Albert Riera (hamstring) and defenders Martin Kelly (ankle) and Sotirios Kyrgiakos (knee) are out and midfielder Alberto Aquilani - who played for the reserves on Wednesday - will not be considered for the Liverpool squad.
Manchester United Team News
Michael Owen may get another start as Wayne Rooney remains a doubt for the Manchester United squad. The United striker has been out with a calf injury since England's World Cup qualifier in Ukraine a fortnight ago. Manager Sir Alex Ferguson is hopeful the former Everton star will be fit to feature on Merseyside but admits it is far from certain.
Veteran Ryan Giggs is poised to return after suffering a knock in last week's defeat of Bolton Wanderers and Patrice Evra has overcome a heel problem. Darren Fletcher (groin) is another doubt while Park Ji-Sung (knee) is set for a couple of weeks on the sidelines.
Wayne Rooney- The United striker picked up an injury while on England duty